Sentence examples for bcr from inspiring English sources

This well-known example of translocation involves the fusion of a proto-oncogene called c-ABL, which is located on chromosome 9, to a site on chromosome 22 known as a breakpoint cluster region (BCR).

BCR and the c-ABL gene produce a hybrid oncogene, BCR-ABL, which produces a mutant protein that aberrantly regulates cellular proliferation.

Their home was a stylistic relic from about 25 years BCR (or Before Changing Rooms ).

The break point occurs in the middle of two genes, one known as bcr on Chromosome 22 and another known as abl on Chromosome 9.

When these chromosomes break, and their parts then join to form a 9-22 hybrid chromosome, they bring together two genes, called BCR and ABL.

CML is unusual because only one mutation, the chromosomal junction between the BCR and ABL genes, drives the disease.

Gleevec, probably the most remarkable anti-cancer drug of the past decade, disables the protein encoded by another fused gene, BCR-ABL.

The novel protein made by the gene which results from this union is known as BCR-ABL.

The exact mechanism by which the newly created BCR-ABL protein gives rise to leukemia is not yet elucidated, but it appears that the fusion protein mimics signaling produced by activated growth factor receptors.

BCR-ABL is one of a class of enzymes known as tyrosine kinases, which are involved in signalling pathways within cells.

Pep Charusanti and his colleagues at the University of California, Los Angeles, looked into how a drug called Gleevec acts against chronic myeloid leukaemia.Gleevec works by preventing the phosphorylation of a protein called Bcr-Abl, which is crucial to the development of the cancer.