Our data demonstrated that GABARAPL1 expression is decreased in BC patients and BC cell line models.
Regarding the effects of pazopanib on BC cell viability, we evaluated whether the reduction of BC cell viability was the result of a pazopanib-induced autophagic cell death.
Finally, the phosphorylation of PHB was required for BC cell proliferation, further implicating the importance of the Akt in BC.
Gene silencing of PHB did not promote BC cell apoptosis.
D: Commonly regulated genes in both ERβ + BC cell lines.
Measurement of Everolimus cytotoxicity on BC cell lines.
Human BC cell lines are a powerful experimental tool.
"Cluster 2" was uniformly composed of ER-negative/HER2-negative BC cell lines (orange lines, Figure 1) and was in complete concordance with the Basal "B" BC cell line subtype described in previous BC cell line studies [ 16- 18].
To investigate if these dependencies are also recapitulated in BC cell lines, we integrated expression data with cbs-smoothed aCGH profiles of each BC cell lines.
Stabilized human BC cell lines expressing endogenous ERα and ERβ at comparable levels are not available.
The authors analysed MCF7 and a parental BC cell line drug-resistance MCF7-ADR.
