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These included known cases of gene battery regulation in tissues such as muscle, lymphocytes, erythrocytes, and liver.
The approach presented here needs to be extended to generate more complete models of gene battery regulation.
The over-represented motifs were validated against the literature, and fell into three main categories: 1) previously described cases of gene-battery-like regulation, 2 previously unreported cases of gene battery-like regulation with some support in a limited number of genes, and 3) hypothetical cases of gene battery regulation (Table 3, Discussion).
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The ( beta_{t} p_{t,v}^{reg} eta_{v}^{chg} ) and ( beta_{t} p_{t,v}^{reg} /eta_{v}^{dsg} ) represent the energy charged to the battery during regulation down and discharged from the battery during regulation up in time period t, respectively.
Faced with a growing battery of regulation, and the bizarre recent phenomenon of health secretary Jeremy Hunt personally phoning trust chief executives to pressurise them to sort out A&E problems, it is terrifyingly easy for boards and senior managers to respond to problems with blame and aggression – the infamous NHS bullying culture that has to be eradicated.
66 predicted cases of over-represented transcription factor binding motifs were validated against the literature and fell into three categories: (i) previously described cases of gene battery-like regulation, (ii) previously unreported cases of gene battery-like regulation with some support in a limited number of genes, and (iii) predicted cases that currently lack experimental support.
A key step in the elucidation of gene battery-like regulation is to detect and functionally test the cis regulatory elements that mediate the co-regulation.
We developed a predictive procedure to screen the mouse and human genomes and transcriptomes for cases of gene-battery-like regulation.
In type (ii) cases, a regulator with some degree of documentation is statistically supported to play a role in gene battery-like regulation.
Most likely, the method will benefit from a more accurate identification of regulatory regions (Crawford-04) We screened the mouse and human genomes and transcriptomes for instances of gene battery-like regulation.
Based on a statistical composite score for motifs in ortholog pairs, and a simulation approach to determine significance levels, we found 21 instances of statistically supported gene battery-like regulation that were conserved between mouse and human.
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