The multi-model scheme contains the trial points (battery of models), which are updated through time by using a modification rule called exploratory move in the PSM context.
For single-locus genotype effects we opted to include a parameter for each genotype (AA, Aa, aa) rather than test a battery of models with a specified penetrance (dominant, recessive, multiplicative penetrance/allele counting), which have one degree of freedom less.
In the next step, an initial mathematical model structure (or battery of model structures) is proposed.
The growing availability of drugs, diets (Orentreich et al., 1993), developmental interventions (Sun et al., 2009), and mutations (Brown-Borg et al., 1996; Ladiges et al., 2009) that extend mouse mean and maximal lifespan provides a battery of model systems in which to look for pathways that may be shared among these different anti-aging interventions.
Based on the two program packages used, two different experiments were carried out, with the aim of identify batteries of models to be exploited for designing new cardioprotective agents from libraries of new chemical entities.
A battery of computational models have been developed to address false-positives due to nonlinear amplification, false-negative allelic drop-out due to amplification bias, non-uniform coverage, and noise that arises during single-cell genome or transcript amplification (Table 2) [40].
On the contrary, stress counteraction has been shown as an effective therapeutic strategy against overnutrition-related glucose disorders in a battery of animal models.
The David Pogue column in Business Day yesterday, about digital cameras under $300, referred incorrectly to the battery of one model, as did an accompanying picture caption.
On Monday night at its design studios in Hawthorne, Calif., Tesla Motors introduced its Supercharger, a glittering monolith capable of bringing the battery of a Model S sedan from flat to full in about an hour.
Male and female 12 weeks-old R6/1 mice and their wild-type littermates were tested on a battery of tests modeling some of the major neuropsychiatric non-motor symptoms of HD: alterations in social interest, social interaction and communication, as well as disturbances in prepulse inhibition of the acoustic startle response (PPI) and circadian patterns of activity.
The multi-model scheme contains a battery of time-varying models which are updated using a modification rule.
