The essential nature of NPC1 for infection in cells derived from mammals of multiple species, including bats, and for infection and in vivo pathogenesis in lethal EBOV infection mouse models argues against the existence of alternative filovirus entry receptors (Carette et al., 2011; Miller et al., 2012; Herbert et al., 2015).
The purpose of the multiple species is because variations in size and shape are a very real and very unpredictable problem for a bat.
Like WNS in hibernating bats, chytridiomycosis has caused precipitous declines among multiple species of wild amphibians.
This finding, and detection of multiple lineages infecting individual bat species, may instead reflect high levels of transmission within and between bat species caused by crowded roosting areas and sharing of roosts by multiple species.
The role of bats in JEV epidemiology has been poorly defined, although the virus has been isolated from bats of various species since 1963 in multiple locations (5, 6 ).
Within North America, distinct RV variants have been associated with rabid wildlife, including foxes, coyotes, raccoons, skunks, and multiple species of frugivorous, insectivorous, and hematophagous bats.
However, due to the diversity of bats at our study sites, it was common to record multiple species on the same file; in these cases, a pass was counted once for each of the species represented.
We detected alphacoronavirus RNA in bats of 4 species: big brown bats (Eptesicus fuscus), 10% prevalence; long-legged bats (Myotis volans), 8% prevalence; little brown bats (Myotis lucifugus), 3% prevalence; and western long-eared bats (Myotis evotis), 2% prevalence.
