Due to the complex chemical composition of TCM drugs and many sources of variations that could lead to batch-to-batch inconsistency, classical quality control measures such as those applied to purified chemical drugs are often not suited to ensure quality of TCM materials and products.
However, typical surface modification methods including chemical conjugation or physical absorption have several limitations such as multistep, complicated procedures, surface denaturation, batch-to-batch inconsistencies, and low surface conjugation efficiency.
These were largely resolved during the course of the study, while similar technical issues regarding needle batch code inconsistencies persisted.
34 Moreover, there can be a great deal of inconsistency between batches.
Integrating both of these dose-response assessment ideologies into the Bayesian framework enables us to create a risk assessment model that accounts for both inter-batch and experimental inconsistencies in the relevant data, and also captures the uncertainty surrounding the toxicity potential of many NMs [51].
Second, because APEL contains only recombinant proteins (albumin, transferrin and insulin), inconsistencies arising from batch to batch variation intrinsic to media components such as BSA are minimised.
However, past studies have shown many concerning issues in regard to the use of batch process such as high residence time, product inconsistencies across batches, high labor cost and difficulty in industrial scale up.
One of the common issues that arises in abrasive machining is the inconsistency of the surface roughness within the same batch and under identical machining conditions.
However, the obstacle encountered in this system is the inconsistency in the enzyme activity and the template specificity among different batches of the RdRp extracts.
The data were uploaded by batch data entry into the study database at the CRSC and then reviewed for inconsistencies and data entry errors.
