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The present work is an attempt to study As and F+ coevality using laboratory based assays which couples fractionation and batch dissolution experiments.
To better understand the chemical fate of ENPs in aquatic environments, solubility of CeO2 NPs was investigated using batch dissolution experiments as a function of pH (1.65 12.5), [phosphate] and particle size (33 and 78 nm).
In batch dissolution experiments with aluminium electrodes, the addition of 30 g m−3 humic acid to a neutral solution of 0.5 mol m−3 NandO4 and 8.8 g m−3 NaCl led to an unexpected increase in the charge yield from 1.0 to ca. 1.5, i.e., the measured concentration of aluminium species in solution was 50% higher than expected from Faraday's law.
The methods were evaluated through a combination of SEM analysis and batch dissolution experiments.
Compared to traditional methodologies, this procedure is far more successful at acquiring a narrow range (45 75 μm) of pyrite particles, as reflected in batch dissolution experiments and SEM analysis.
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Extensive investigations with silica gel, gypsum, sucrose and calcium carbonate has revealed that depictions of the kinetics of batch-dissolution tend to cluster into those from studies of either sedimentary minerals, e.g., calcite, or silicate and alumino-silicate minerals.
A model has been presented which successfully simulates the experimentally observed integral batch reactive dissolution rate data while accounting for the poly-dispersity of the solid particulate charge.
The release rate was determined for three tablets of each batch using dissolution testing apparatus II (paddle method).
The working group organized in the Generic Committee focusing on itraconazole found batch-to-batch variations in dissolution profiles of the originator capsule product, which suggested possible differences in the performance of reference batches for the development of generic products.
The Committee recommended the innovator company to improve the process in order to minimize the batch-to-batch variation in dissolution profile and to meet the target bioavailability, after confirming the absence of possible adverse effect cases in clinical reports.
In these samples of batch production and dissolution, we recommend control with routine chemistry tests and with dialysate control after dilution by machines.
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