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In addition, batch differences can be observed [ 50].
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The differences can be assigned mainly to the use of different cell lines and cultivation conditions like media composition, aeration mode, pH control and culture type e.g. suspension or immobilized, batch or fed-batch.
Differences can be shown.
This difference can be considered a small one and in the range of the possible deviation in different batches.
The difference can be huge.
The difference can be dramatic.
The difference can be jarring.
The difference can be amazing!
Many laboratories buy large batches of serum (held in store by the supplier) to avoid batch variability; batches can be kept at −80 °C without noticeable loss of function.
Each batch of derivatized cellulose is thoroughly characterized before utilized in tablet formulations as batch-to-batch differences can affect drug release.
Batch effects are wide-spread occurrences in genomic studies, and it has been shown that noticeable variation between different batch runs can be a real concern, sometimes even larger than the biological differences [ 1- 5].
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