This method balanced the treatment groups on the basis of stage of disease (stage I/II, III or IV), KPS (60 70% vs 80 100%), gender, disease status (newly diagnosed vs recurrent vs recurrent + other treatment), measurable disease (measurable vs non-measurable) and study centre.
We evaluated the entire patient population and patients divided on the basis of clinical stage (stage I-II, stage III, and stage IV) in comparison with the healthy control group.
The detailed molecular basis and stage of cancer development at which this instability arises is actively being pursued.
The UK Medical Research Council Framework for the Development and Evaluation of Complex Interventions (2008) specifies "establishing a theoretical basis" as Stage 1 in the development of any complex intervention [ 27].
McArdle et al [ 18] also used hierarchical clustering and found 31 genes that could distinguish tumours on the basis of stage and differentiation.
These tumors were selected on the basis of stage 2 or 3 at presentation and/or age < 50 and a balance between the 3 clinical subtypes.
Attempts to explain socioeconomic differences in survival on the basis of stage and treatment have also produced conflicting results, which may reflect differing health service provisions and socioeconomic structures in the relevant countries (Thomson et al, 2001).
This last suggestion is consistent with our data, showing more active staff-rated involvement from more recovered service users, which has clinical implications for tailoring the balance of power in decision-making on the basis of stage of recovery.
This system is used to describe the anatomical extent of the disease at diagnosis based on primary tumor size and extent of tumor growth (T), regional lymph node metastasis (N) and distant metastasis (M), and is the basis for stage grouping these patients [ 7, 8].
Henry Ball's history of the AWC, Of Responsible Command (1983), identified a number of distinct incarnations of the institution on the basis of stages in its evolution.
