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The commonly used avirulent M. tuberculosis strain H37Ra was derived from virulent strain H37 in 1935 but the basis of virulence attenuation has remained obscure despite numerous studies.
To further understand the molecular basis of virulence, Obenauer et al. first sequenced the genes of a large number of H5N1 viruses isolated from wild birds and poultry, providing an invaluable resource for many investigators.
Recent advances on the molecular basis of virulence and immune evasion have helped identify var2csa as a PAM-specific var gene.
This work will serve as a baseline for future studies into the genetic basis of host preference, and in particular the molecular basis of virulence in M. bovis.
Consequently, meningococcal mCGH studies have already provided valuable insights into the genetic basis of virulence in this accidental pathogen [9], [16], [17], [18].
To investigate the genomic basis of virulence, mCGH analyses of isolates from patients and healthy carriers are particularly useful for pathogens for which a suitable animal model of disease is lacking such as for N. meningitidis [39].
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We wanted to classify the C. albicans strains on the basis of their virulence to the fly independent of rank, because although ranking revealed a statistically significant correlation for clinical isolate virulence between mice and flies, it did not provide an instructive way with which to look at the data.
A major research goal has been to identify the molecular basis of the virulence of H5N1 viruses in humans (1, 2).
On the basis of their virulence in chickens, influenza A viruses of the H5 and H7 subtypes can be further classified into highly pathogenic avian influenza (HPAI) and low-pathogenic avian influenza (LPAI) viruses.
The genetic basis of Xenorhabdus virulence is not yet fully understood.
To date six categories of DEC have been defined on the basis of specific virulence properties [ 6, 7].
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