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Recent genome-wide PGx studies have provided some insight into genetic basis of variability in drug response.
Although most have studied variability at the level of the entire domain, a few studies have investigated the basis of variability of DBL domains in depth [20], [23], [24], [27].
This re-confirms the importance of analyzing the basis of variability, particularly in multi-conformer representations of low resolution data.
The feedback loop between NMD and UPR implies that the differential sensitivity of cells to activate the UPR may also be the basis of variability in NMD efficiency.
These include G types G1, G2, G3, and G4 and P types P[4] and P[8] (on the basis of variability in the outer capsid proteins VP7 and VP4, respectively).
In most of the studies included in our meta-analysis, it appears that patients were not selected on the basis of variability in SBP before randomization, as is usually done when antihypertensive compounds are developed.
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The extent of functional recovery is highly variable among patients, and the basis of this variability is not known.
Can one make long-term spending decisions on the basis of such variability?That brings up the related issue of the future path of oil revenues.
The choice has been done on the basis of the variability of the ridges area size.
Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood.
Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability.
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