This enables re-use of valuable phenotypes from historical datasets for, e.g. GWAS or genomic prediction.
The site includes hundreds of valuable phenotype data for generations of mice (Maddatu et al., 2012).
The CPRD is much larger than the UK biobank and would be particularly valuable to improve our understanding of the genetic basis of rarer phenotypes, if these could be linked to biological samples.
However, even in the absence of whole-genome genetic association approaches, our characterization of these 1227 cDNA sequences provides an extremely valuable resource for candidate gene approaches aimed at investigating the genetic basis of feline phenotypes.
For example, the genotypic determinant of a valuable phenotype in one species could be directly tested for its involvement in a similar phenotype in another species [ 33].
Indeed, even if gene function is primarily assessed on the basis of altered phenotypes associated with gene disruption, knowledge of spatio-temporal expression patterns of a given gene represents valuable information for assigning a putative function.
Chong, J. X. et al. The genetic basis of mendelian phenotypes: discoveries, challenges, and opportunities.
Progress in the field of strain engineering is being made by identifying the genetic basis of complex phenotypes, engineering new phenotypes, and combining beneficial phenotypes in industrial hosts.
Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested.
