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Experiments were conducted first to capture the fundamental deformation and failure patterns and they served as a basis of validation for both the FE and analytical models.
This hierarchy generally forms the basis of validation studies [ 7, 8] and studies modeling the determinants of exposure [ 9, 10].
Samples with a cycle threshold value of <35 were considered positive on the basis of validation data using the cloned membrane protein gene (data not shown).
On the basis of validation studies on more patient sets, miR-801 and -214 showed higher expression in patients with sporadic MPNST and patients with NF1 and MPNST than patients with NF1 [ 108].
Among the putative Klf5 direct targets, we decided to start by analyzing 23 genes that were selected on the basis of validation by qPCR (Additional file 7) and their expression profile during ESC differentiation.
Corresponding instruments (for example, Sidney Swallowing Questionnaire and Hearing Handicap Inventory for Adults – Screener) were selected on the basis of validation studies completed in other patient populations [ 35, 36].
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14 Most studies reported the accuracy of outcome ascertainment on the basis of historical validation studies; only two studies specifically cross checked or validated outcomes for this analysis.
Local crack propagation behaviors are also discussed on the basis of this validation.
While a causal link between target genetics and side effects is biologically plausible genetic and pharmacological perturbation of a protein should lead to similar phenotypes, and this logic is the basis of genetic validation of drug targets25,26 there are many potential confounders that could instead be explaining the enrichment we observe.
It is clear that the improvement of the two responses forms the basis of the validation of any analytical method, and affects all the figures of merit: accuracy (trueness and precision), capability of detection, robustness, sensitivity, etc.
On the basis of model validation, system optimizations of both the existing pilot household and the typical rural house with good building insulation were undertaken to figure out the system economical efficiency in the rural regions of Beijing.
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