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It is a multi kinase inhibitor, which can prolong the survival rate up to 20% and the only systemic agent approved for treating advanced, unresectable HCC on the basis of two phase III clinical trials.
Before applying this revision, we first review the theoretical basis of two phase flow performance in vertical conduits and also recall some concepts of asphaltene behavior.
It was recently approved for treatment of SLE on the basis of two phase III studies that showed positive results [ 11, 12].
The approval of rilpivirine was granted on the basis of two Phase III triple combination studies, known as ECHO and THRIVE, in which rilpivirine was studied in combination with two nucleoside drugs (most commonly tenofovir and emtricitabine), in comparison with the use of a different non-NRTI, ie, efavirenz, to suppress viral load in antiretroviral-naïve individuals.
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On this basis, some general rules for the design of two phase alloys, taking into account the mechanical properties of both phases and the morphological parameters of microstructures, are drawn.
1 A later trial, MALEO, with change in spine bone density as the primary end point, was conducted to seek extension of the treatment indications to men. 2 Strontium ranelate was registered for use in postmenopausal osteoporosis in Europe in 2004 on the basis of the two phase 3 trials, and subsequently in more than 70 countries.
On the basis of the results of five phase I studies and in consideration of the safety and efficacy, a dose of 50 mg m−2 per day was defined as the recommended dose (RD); TAS-102 was given twice a day within 1 h after a meal for 5 days a week for 2 weeks, followed by a 2-week rest (Green et al, 2006; Hong et al, 2006; Overman et al, 2008a; 2008a).
Retrieval trials consisted of two phases.
Abstractly, DEGAS consists of two phases.
The survey consisted of two phases.
Each day consisted of two phases.
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