On the basis of the three randomized, placebo-controlled phase IIb/III trials in adults with POS, 30– 32 lacosamide was first approved in 2008 (by both the U.S. Food and Drug Administration FDAandand the European Medicines Agency (EMA)) as adjunctive therapy in the treatment of POS in adults (aged ≥17 years in the United States and ≥16 years in Europe).
These studies form the basis of the findings and consist of five randomized controlled trials (RCTs), five cluster RCTs, one interrupted time series study, one crossover designed study, one pre-post study, and one quasi-experimental study (Additional files 4 and 5).
The Kronos Early Estrogen Prevention Study, or Keeps, is one of two randomized placebo-controlled trials that will test the hypothesis.
Dr. Woloshin and Dr. Schwartz are scheduled to present the results of two randomized trials, published last week in Annals of Internal Medicine, in which they examined how well drug fact boxes worked on several hundred people.
Dependency at discharge was studied in one review [ 101] and it was found, on the basis of two studies (one randomized and one non-randomized) that patients from the care pathway group were more dependent at discharge than the control group.
Much debate exists whether linezolid should be considered the drug of choice for MRSA pneumonia on the basis of two retrospective analyses of pooled data from randomized trials comparing linezolid and vancomycin for nosocomial pneumonia [ 50, 51].
The practice in MM of post-ASCT maintenance therapy using thalidomide has been established on the basis of results from four randomized clinical trials that suggest the approach improves PFS.
Ranges between the dashed lines represent 95% CIs on the basis of the randomized sequences of formation changes.
Treatments including MSW levels at (0 (control), 15 (MSW1), 30 (MSW2) and 60 (MSW3) t ha−1 dry weight) and usage time (yearly (T1) or biyearly usage (T2)) were tested in a factorial experiment on the basis of a completely randomized block design with three replications.
In three randomized controlled trials, six months after the trauma, patients who had received treatment were three times less likely to develop P.T.S.D. compared with members of the control group, which received only supportive counselling.
