Sentence examples for basis of this specificity from inspiring English sources
Previous studies have implicated the homeodomain as a major determinant of biological specificity within these proteins, but have not established the physical basis of this specificity.
The molecular basis of this specificity remains to be clarified but may be explained by its interaction with the RhoGEF Vav.
Understanding the molecular basis of this specificity would improve our ability to incorporate F1-40 into multianalyte assays able to detect more than a single serotype.
In order to describe the genetic basis of this specificity of Xff strains compared to most other xanthomonads, we analyzed the tyrosine degradation pathway (http://biocyc.org/META/new-image?object=TYRFUMCAT-PWY).
In the Pasteurellaceae and Neisseriaceae the molecular basis of this specificity is preferential binding of the uptake machinery to short DNA sequences present in thousands of copies in each species' genome.
Interestingly, NCOA4 has been reported to bind FTH1, but not FTL, in cell extracts (Dowdle et al., 2014); however, the biochemical basis of this specificity is unclear, especially given that FTH1 and FTL are 53% identical and 66% similar in primary sequence.
It would be interesting to explore the basis of this tissue specificity, possibly related to different kinases phosphorylating p53.
The structural basis of this orthogonal specificity would undoubtedly be interesting, and a recent report in BMC Structural Biology from the Merck Global Structural Biology group (Soisson et al. [ 1]) has now met that expectation.
On the basis of this broad specificity, it is likely that the AHL lactonase can also hydrolyze many non-natural quorum-sensing agonists and antagonists that are N-substituted homoserine lactones (45) and may also reflect a selective pressure to hydrolyze a large variety of AHLs found in native B. thuringiensis growth environments.
This together with mutagenesis and deletion studies based on the comparisons will help to understand the basis of the specificity of the TF interactions.
