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The basis of this selective expression involves that part of the DNA which is noncoding.
To understand the basis of this selective cytotoxicity, we constructed a fully functional ecdysone-inducible GFP OGT.
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This could be explained on the basis of the selective disadvantage of non-trimeric SSR variants in coding regions, possibly causing frame-shift mutations [ 49].
This pathway was originally identified on the basis of the selective internalization of various GPI-APs such as the folate receptor [4], but has also been shown to facilitate the entry of: cholera toxin bound to its ganglioside receptor GM1[5]; the vacuolating toxins aerolysin and VacA[6]; and bulk fluid phase (pinocytosis) in diverse mammalian cells [4].
After initial dissolution of the spent nuclear fuel in nitric acid, uranium and plutonium recovery from ultimate waste (fission products and minor actinides) is operated by a liquid liquid extraction process (PUREX process) and plutonium partitioning from uranium is run on the basis of the selective reduction of Pu and its back extraction.
Beyond its diagnostic applications, trimerbodies offer promising therapeutic opportunities on the basis of the selective delivery of bioactive molecules to the target tissue.
By contrast, rationalization of the basis of the selective binding of clozapine N-oxide to a muscarinic RASSL (13) was only possible post hoc (12).
In fungi ergosterol serves an analogous function to cholesterol in mammalian cell membranes and forms the basis of the selective toxicity of many antifungals.
Such dominance of triplets over other repeats in coding regions may be explained on the basis of the selective disadvantage of non-trimeric SSR variants in coding regions, possibly causing frame-shift mutations [ 41].
The basis of the selective regulation of a subset of NRSE-containing genes includes their mid-range binding frequencies to NRSF, so that moderate fluctuations in NRSF levels influence the degree of their binding.
Therefore, a thorough interrogation of the mechanisms of how iron excess contributes to tumorigenesis and the molecular basis of the selective efficacy of iron deprivation would not only further our understanding of cancer biology but also improve the design of targeted chemotherapy for better clinical outcomes.
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