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We examined the basis of this differential effect of translocating and non-translocating γ subunits using a FRET sensor based on αq-CFP and YFP-γ interaction.
The molecular basis of this differential sensitivity remains to be determined; since the Shh receptor component Smo appears to be expressed evenly in both, medial and lateral mDN (data not shown).
The basis of this differential effect of light on uvh6 anthocyanin regulation is unknown.
We sought to clarify the basis of this differential enteric toxicity.
To determine the basis of this differential effect of the time of immunisation, we assessed the proliferative responses of splenic lymphocytes from the immunised mice.
Thus, there is evidence for a differential biochemical activity of D6PKs and PID/WAGs but the molecular basis of this differential activity remains to be determined.
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We were interested in a better understanding of the basis for this differential response to various anti-VEGF therapies that may help to identify a predictive marker(s) of response, and would greatly aid in the identification of a suitable patient population for treatment.
Interestingly, while Nrf2-regulated antioxidant and detoxifying (phase I/II conjugating) enzymes were downregulated in RS cells, Nrf2-regulated molecular chaperones (including members of Hsp22, 40 and 90 families) were largely upregulated in the same cell type; the basis for this differential regulation of distinct subsets of Nrf2 target genes is currently unclear.
The structural basis for this differential propagation of conformational dynamics is not apparent from examination of the crystal structures of the wild-type proteins.
While the molecular basis for this differential regulation of Fgf21 by fasting and caloric restriction is not yet known, these data indicate that FGF21 is not an endogenous mediator of the caloric restriction response.
These studies demonstrate a profound difference in stability of the B-pentamers in Stx1 and Stx2, illustrate the mechanistic basis for this differential stability, and provide novel reagents to test the basis for differential pathogenicity of these toxins.
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