The statement 'Previous attempts using several apo and complex structures... yielded the first cognate ligand-bound structure and provided the structural basis of this fundamental cellular process' is misleading.
Here, we present a systems view of the spindle assembly checkpoint in which we modularize the complexity of the components into the key communicating elements and consider the measurements and modelling of these elements that have started to reveal the quantitative basis of this exquisite cellular control mechanism.
On the basis of the cellular results, the 64Cu/NOTA-BVD15 64Cu/NOTA-BVD15ars to have a potential for the targeting of NPY-Y1R positive tumors.
On the basis of the cellular architecture of the developing cortex, one model suggests that oblique or vertical spindle orientation influences the inheritance of the apical domain [ 59].
During blockage of the ATP synthesis pathways, the ATP concentration in the organ diminished on the basis of the cellular ATP consumption rate.
On the basis of the cellular morphology, differences among the nuclei of enterocytes, goblet cells, and lymphocytes were clearly distinguishable at 400× magnification.
Simple network topologies, as negative feedback loops with a buffering node or incoherent feedforward loops, can be at the basis of the cellular implementation of adaptation [ 71].
To quantitatively understand the cellular basis of this tissue shape change, we must determine the global patterns of these cellular events throughout the wing blade.
Both total synovial HDAC activity and HDAC1 expression were associated with increased TNFα production, and in attempting to understand the cellular basis of this relationship, the authors found that TNFα stimulation of RA FLSs led to transient increases in cellular HDAC activity and HDAC1 expression.
We have made good progress in understanding the cellular basis of this, and its control by genes.
