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Because of the extended larval period in Xenopus, the molecular basis of these alterations has not been well studied.
Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown.
The mechanistic basis of these alterations is not yet known, although it is plausible that epigenetic modifications of maternal tissues may influence metabolism later in life and, perhaps, during subsequent pregnancies.
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I would also want to identify human patients with rare but definable alterations in central nervous system function, and to use whole-genome sequencing to figure out the genetic basis of those alterations – and then to study those genes and see where they lead.
Increased expression of Fas receptor and lower levels of sFas may provide the basis for these alterations that in turn may promote the rupture of tendons.
On the basis of these metabolic alterations, we surmised that the pathogenic impairments conferred by INPP1 knockdown might also result from lowered glycolysis and LPA synthesis.
The proposal of kallikreins besides PSA as cancer biomarkers has been already reported, on the basis of the alterations in expression of many members of this family in several cancers [ 1– 3].
In this view, in recent years a number of studies have investigated gene expression profiles of normal and pathological testis, providing useful information about the molecular basis of the alteration of the spermatogenesis [ 5, 9].
By further identifying the neuronal basis of these parasite-induced alterations of host behavior, we hope to increase our understanding of the neurobiology of the selection and initiation of behaviors and the associated neural mechanisms underlying changes in responsiveness, both prime issues in the study of motivation.
Despite these observations, unsupervised hierarchical cluster analysis performed in our series was unable to separate tumors on the basis of chromosomal alterations.
However, very little is known about the molecular and cellular basis of such alterations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com