Sentence examples for basis of their conservation from inspiring English sources
and designed on the basis of their conservation level for viral strain discrimination.
According to previous studies [ 27], two shRNA target sequences were chosen on the basis of their conservation among the major HBV genotypes adr, adw, ayr and ayw.
The KL divergence directly assesses the difference of two distributions and therefore increases specificity for similar distributions, but makes no distinction on the basis of their conservation, which is however a property of the column score.
On the basis of their conservation among apicomplexan genomes, we decided to generate parasite strains expressing tagged versions of PRP or DrpB in order to test if they are targets of TgCDPK1 in vivo.
Noteworthy, SDPsite and SDPclust are complementary to rate4site, which predicts functionally important positions on the basis of their conservation, in the sense that they identify another set of functionally important residues, the ones accounting for differences in specificity.
In this study, we performed comparative analyses of phosphosites using a wide variety of methods and extracted physiologically important phosphorylations on the basis of their evolutionary conservation.
These data suggest that, despite selecting on the basis of conservation, conserved intergenic and conserved exonic sequences appear to be subjected to different strengths of selective pressure within the human population.
A TF-specific GOOFE was defined for each L. plantarum LacI-family TF on basis of context conservation and then the upstream regions preceding the conserved operons/genes were selected (see Methods for the precise procedure).
Wilson and Nierhaus [ 51] have proposed that the E site is ancestral on the basis of its conservation across all three kingdoms, and they identify three highly conserved nucleotides critical for the binding of the CCA end of the E site tRNA.
Alternatively, various bioinformatics methods can be employed to give an indication of whether an amino acid substitution is likely to damage protein function on the basis of either conservation through species or whether or not the amino acid change is conservative.
The latter has been the basis of traditional resource conservation, that is, conserving resources solely for their economic use and human consumption" (Meffe 2000).
