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The results of the assessments are used to construct response surfaces from which the damage statistics forming the basis of the vulnerability curves are generated through re-sampling.
In addition to their greater vulnerability to bacterial hemolysins, increased susceptibility of neurons expressing the G93A mutant in their SOD1 to the attack of activated immune cells may be the pathophysiological basis of the vulnerability of the nervous system of patients with motor neuron disease to systemic infections.
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These data suggest a basis for the vulnerability of the kidney to injury during cardiac surgery.
A previous study showed that DA quinones, toxic metabolites that lead to PD, could promote the assembly of tau into fibrillar polymeric tau in vitro [ 15] which suggests a potential interplay between DA and tau in vivo and may provide a basis for the vulnerability of DA neurons.
Indeed, the identification of torsinA-sensitive neural classes throughout the CNS is motivated by the expectation that understanding the mechanistic basis of this vulnerability will reveal key aspects of torsinA biology critical to disease pathogenesis.
Previous studies investigating punishment-induced suppression of cocaine seeking or taking have demonstrated that, after a long, but not a short, cocaine-taking history, ∼20% of animals persist in compulsively seeking cocaine (Deroche-Gamonet et al., 2004; Pelloux et al., 2007, 2012), thereby providing an opportunity to investigate the neural basis of this vulnerability.
This section presents the child poverty estimates for Vietnam on the basis of the Child Vulnerability to Poverty methodology and MICS data.
Some of the aspects contributing to denial and resistance to treatments can be automatic and unmotivated whilst others are consciously generated by patients who actively oppose to treatment, also on the basis of the biological vulnerability of altered reward and inhibition underlying these disorders [ 7, 8].
In order to plan and implement adaptation strategies, the first crucial step is to identify geographical areas on the basis of their vulnerability to climate change.
This work presents a method proposal to predict cumulative impacts on the basis of landscape vulnerability evaluation.
At this stage, the basis of selective vulnerability in MSA remains unclear.
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