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The test is specific to GSH on the basis of the specificity of the GSH reductase enzyme to GSH: the rate of accumulation of TNB is proportional to the concentration of GSH in the sample.
However, the limited population coverage of some HLA alleles may be alleviated by focusing on T cell epitopes recognized by HLA supertypes that bind largely overlapping peptide repertoires on the basis of the specificity for the main anchor positions of the presented peptides [10], [11].
What is the mechanistic basis of the specificity of dPob towards multispan membrane proteins?
To interrogate the basis of the specificity of 4-MDDT for AKR1C3, we performed ligand-protein docking calculations using our published AKR1C3 structure (Lovering et al, 2004).
This together with mutagenesis and deletion studies based on the comparisons will help to understand the basis of the specificity of the TF interactions.
Twenty-five BTV serotypes have been identified on the basis of the specificity of reactions with neutralizing antibodies generated by their mammalian hosts (3 ).
Similar(51)
The third aim was to identify sequence differences that may denote evolutionary changes that serve as the basis for the specificity of action of these SS isoforms.
Despite these biological studies, the structural basis for the specificity of substrate interactions of AUS remains elusive.
We do not understand the basis for the specificity of the JAK2V617F mutation in clonal disorders of the myeloid, but not lymphoid, lineage, nor has the basis for the pleiotropic phenotype of JAK2V617F-associated myeloproliferative disorders been delineated.
The direct interaction of transcription factors (TFs) with DNA regulatory sequences forms the basis for the specificity of transcriptional regulation.
These data suggest a physical basis for the specificity of intracellular vesicular transport.
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