Sentence examples for basis of the selectivity from inspiring English sources
An X-ray crystal structure of one of the designed compounds bound to ERRγ LBD confirms the molecular basis of the selectivity.
In humans, the structural basis of the selectivity of genistein for ERβ versus ERα has been linked to two critical positions in the ligand binding pocket, Met 336 and Ile 373, which are replaced by a Leu and a Met respectively in ERα ([23]; see Figure 6A).
Two major types of GABA receptors (GABA-A and GABA-B) have been identified, on the basis of the selectivity of agonists/antagonists and coupling mechanisms.
It is believed that the diversified spatial structures resulted from divergent C-terminal region of CIPKs explain the molecular basis of the selectivity of certain CBLs towards particular CIPKs.
To understand at the molecular level the basis for the selectivity of Cpds 3, 30, 188, 3-2 and 3-7 and the absence of selectivity in the case of Cpd 30-12, we compared the amino-acid sequences and the available structures of the Stat3 and Stat1 SH2 domains and also examined how each compound interacted with both.
The molecular basis for the selectivity of this regulatory mechanism has to be better addressed and explained.
To examine the structural basis of this selectivity, we compared the sequences and structures of these two proteins.
The basis of this selectivity relies on protein-protein interactions between the E3 ubiquitin ligase and the target protein, as illustrated by engaged proteins that are not degraded as a result of unstable ternary complexes with PROTAC-recruited E3 ligases.
Further analysis of the critical targets of the oncogenic ETS factors is needed to reveal the basis of this selectivity.
Using a structure of a NagZ inhibitor complex we provide insight into the molecular basis for the selectivity and potency of this inhibitor.
Full elucidation of the molecular basis of this selectivity is therefore needed to provide a framework for the rational design of feasible anti-HCV drugs or intervening applications.
