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After initial dissolution of the spent nuclear fuel in nitric acid, uranium and plutonium recovery from ultimate waste (fission products and minor actinides) is operated by a liquid liquid extraction process (PUREX process) and plutonium partitioning from uranium is run on the basis of the selective reduction of Pu and its back extraction.
Beyond its diagnostic applications, trimerbodies offer promising therapeutic opportunities on the basis of the selective delivery of bioactive molecules to the target tissue.
This pathway was originally identified on the basis of the selective internalization of various GPI-APs such as the folate receptor [4], but has also been shown to facilitate the entry of: cholera toxin bound to its ganglioside receptor GM1[5]; the vacuolating toxins aerolysin and VacA[6]; and bulk fluid phase (pinocytosis) in diverse mammalian cells [4].
By contrast, rationalization of the basis of the selective binding of clozapine N-oxide to a muscarinic RASSL (13) was only possible post hoc (12).
This could be explained on the basis of the selective disadvantage of non-trimeric SSR variants in coding regions, possibly causing frame-shift mutations [ 49].
In fungi ergosterol serves an analogous function to cholesterol in mammalian cell membranes and forms the basis of the selective toxicity of many antifungals.
Similar(48)
First and foremost is the molecular basis for the selective consequences of the SAM mutation on a selected subset of p63 target genes.
To determine the biochemical basis for the selective effect of capsaicin on the context of ROS generation in K-ras transformed cells, NOX activity was assessed before and after capsaicin treatment.
The aim of the current study was to determine the molecular basis for the selective expression of the pri-miR-375 gene in pancreatic islets.
However, the basis for the selective role of the SAM domain in control of p63-dependent transcription remains elusive, and a conclusion of the present study is that it may be best understood in vivo, possibly by proteomic approaches to identify functionally relevant, associated partners.
The idea of solving for sets of nominal and nuisance parameters from different subsets of data depending upon their SNRs in a hierarchal framework is the basis for the "selective" part of the method.
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