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Often the difficulty in this approach is elucidating the genetic basis of the phenotypes that emerge as a result of evolutionary mechanisms.
This makes it difficult to draw firm conclusions regarding the anatomical basis of the phenotypes displayed by 5-HTT OE and KO animals.
More information about the molecular basis of the phenotypes displayed during mammalian hibernation may lead to the development of novel clinical approaches for the treatment of injuries and disease in humans.
On the basis of the phenotypes of the mutant and overexpressors (complemented lines), it is highly likely that MpSIG1 is involved in the transcription of a wide range of transcripts and that its function overlaps with and/or is complemented by those of other sigma factors.
In a similar fashion, for the purpose of assessing our method we were unable to include the COGs with unknown function, but ideally we would like to extend this method to make predictions regarding possible functions of these uncharacterized COGs on the basis of the phenotypes they are most associated with.
Finally, in light of the criticism of PST as a substitute for QST, it should also be kept in mind that common garden estimates of QST may be inappropriate to compare to FST because the genetic basis of the phenotypes on which selection may potentially act may be partly genetic but non-additive (i.e. epigenetic), or environment-dependent.
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Chaiworapongsa, T. et al. Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa.
On the basis of the phenotype and genotype data, we delimited the candidate region of the QTL to a 1,798-kb 1,798-kb between RM5503 and RM17525.
To further confirm the basis of the phenotype, we examined the expression of markers of prehypertrophic and hypertrophic chondrocytes in transverse sections through the limbs and vertebrae at times before an overt effect on mineralization was apparent.
A frequent objection to this class of methods is that they cannot be applied to cases where little is known about the molecular basis of the phenotype (no confirmed disease genes, fragmentary understanding of the biological cascades involved).
Food intake is centrally regulated [34] and Eps8 is expressed in the brain [8], raising the possibility that alterations in the CNS are at the basis of the phenotype.
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