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The basis of the developmental defects of r-protein mutants is unclear.
The differential expression of the miRNA was evaluated on the basis of the developmental phase of the samples.
The implication for practice is that programmes need to be offered to parents on the basis of the developmental stage of their children.
Based on the evidence for a genetic/neurobiological deregulation as the basis of the developmental course of ADHD, studies highlighting preschool age, school age/adolescence, and adulthood were selected.
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The examination of carotenogenic promoters also provides a basis for the developmental, coordinated upregulation of carotenogenic genes.
The occurrence of such a mechanism in higher organisms such as the mouse may be the basis for the developmental establishment of differential mitochondrial function but must also explain the tissue-specific variations in ETC activities in post-natal tissues.
On the basis of these developmental data, we can hypothesise that, during the early stages of cortical development (when the VZ is very actively proliferating and gives rise to the post-mitotic neurons that migrate to form the deep layers and the precursor cells for the SVZ), one hit is sufficient to modify the future lineage of some but not all progenitor cells in patients with Type II FCD.
Although further work is needed to test these hypotheses and to understand the basis of these developmental changes, they do contribute to a general increase in biomass that is likely to further improve the effectiveness of any biotechnological application of these discoveries.
Understanding the molecular basis of the original developmental mechanisms, and the modifications that occurred during co-evolution with the host, is not only fundamental to our understanding of parasitism but also highly relevant for the design of anti-parasitic drugs and vaccines.
We sought to probe the basis of the regulation of developmental branch pruning by the EGFR.
Information-rich cases were selected on the basis of the following criteria: developmental stages of CRM as assessed with the instrument, hospital type, hospital size, and language region [cf. [ 30]].
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