Sentence examples for basis of the defect from inspiring English sources

The subtle differences that have been uncovered between Sar1A and Sar1B in these studies might also provide an explanation for the molecular basis of the defect in CMRD.

The above data suggest that abnormal cytokine secretion is not the basis of the defect in the T-dependent antibody response.

Although we cannot precisely map the basis of the defect in VAND in the present cross, future backcross studies could be used to identify factors required for efficient transmission in the cat.

The familial and molecular basis of the defect in both species is poorly understood although a previous description of the pattern of inheritance in a canine model in the Newfoundland dog breed suggested either an autosomal dominant with incomplete penetrance or a polygenic mode of inheritance (Pyle and Patterson 1976).

DOI: http://dx.doi.org/10.7554/eLife.11785.012 To define the molecular basis of the defect in interaction between EBOV and EhNPC1, we generated a panel of NPC1 domain C chimeras comprising sequences from permissive RaNPC1 and nonpermissive EhNPC1, and tested them in the GP-binding ELISA.

To investigate the molecular basis of the defects, we examined the mRNA levels of selected genes associated with synthesis (tpsA, tpsC and orlA) or breakdown (treA and treB) of trehalose [21] [24, Christophe d'Enfert, personal communication].

Congenital heart defects are frequently observed in infants of diabetic mothers, but the molecular basis of the defects remains obscure.

The obvious utility of mouse ciliopathy models is in understanding the cellular and molecular basis of the defects.

In order to understand the molecular basis of the defects in more detail, we analysed the activity of mitotic signalling proteins and found that activation of Aurora B did not occur in cells in which RASSF7 was knocked down.

Further work will be required to establish the basis of the defects observed in ILK-deficient mice, and whether these result from disruption of protein complex formation and/or kinase activity.

To determine the cell biological basis of this defect, we investigated the epithelia that will produce denticles.