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Recent efforts to unravel the molecular basis of synaptic specificity have begun to define the mechanisms that match pre- and post-synaptic partners and thereby establish the overall wiring pattern.
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In this way, loss of synaptic specificity molecules can cause widespread circuit dysfunction.
"It's consistent with comparative genomics research indicating that the molecular basis of synaptic plasticity was modified in human evolution," he says.
Firstly though, I shall further consider the significance of PSD structure in research into the molecular basis of synaptic plasticity.
Research into the molecular basis of synaptic plasticity has converged on the regulation of AMPAR phosphorylation by enzymes that respond to postsynaptic Ca2+ entry.
On the basis of synaptic input alone, we would be unable to distinguish between many of the potential computations subsumed by the SN and VTA.
The coincidence between the onset of the calcium signal and asynchronous release was further compared on the basis of synaptic charge entry.
Thus one prediction of this model, not explored by Neves et al., is that PKA phosphorylation of PDE4s contributes to synaptic specificity.
We provide novel evidence for neurochemical and synaptic specificity of two complementary circuits linking one such system, the prefrontal cortex with the ventral anterior thalamic nucleus in primates.
Although fertilization is strictly species-specific, very little is known about the molecular basis of such specificity.
β-Glucosidases may be classified into three groups on the basis of substrate specificity.
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