Sentence examples for basis of substrate transition-state from inspiring English sources

On the basis of substrate transition-state mimic concept of HIV protease, a series of small-sized dipeptide inhibitors containing hydrophilic carboxyl group were designed and synthesized.

Recently, we reported substrate-based β-secretase (BACE1) inhibitors with a hydroxymethylcarbonyl (HMC) isostere as a substrate transition-state mimic.

Recently, we reported substrate-based pentapeptidic BACE1 inhibitors possessing a hydroxymethylcarbonyl isostere as a substrate transition-state mimic.

Recently, we reported potent substrate-based pentapeptidic BACE1 inhibitors possessing a hydroxymethylcarbonyl isostere as a substrate transition-state mimic.

While the use of substrate and transition-state analogues as a starting point for inhibitor design is common, the rationale there is one of achieving affinity: because substrates and transition-states bind to the target, their analogues could bind as well.

This may be attributed to the mixture of RIG-I populations (i.e. RIG-I bound to substrate, transition state and product) undergoing active hydrolysis over the time period of data collection (5-15 min)., perhaps resulting in significant population of the transition state conformation.

The inhibitor appears to mimic the substrate transition state, which may help explain the potency of this inhibitor and the catalytic mechanism of pyrimidine nucleotide phosphorylases (PYNPs).

Complexes with substrate, transition state and product analogues reveal reaction coordinate motion and catalytic interactions.

Most current HIV protease inhibitors were designed to mimic the substrate transition state.

Network structures are generated from the equilibrium occupancy on the basis of transition-state theory formulation on 2D lattice approximations.

On the basis of transition-state (TS) energies, pathway 1 is favored.