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Our strategy was to first define versions of CD4 and Vpu that differ in their membrane interactions and degradation and then use these model clients and nonclients to investigate the basis of substrate discrimination during membrane protein triage.
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The reconstituted system permitted quantitative mechanistic analysis to reveal key aspects of substrate discrimination and commitment for degradation.
Future studies using purified enzymes will be required to measure specificity constants and elucidate the structural basis for substrate discrimination by these two enzymes.
Despite the potential importance of these lactonases in quorum-quenching applications, the basis for their substrate discrimination and catalytic rate enhancements remains unresolved.
These mechanisms contribute to the specificity of protein kinase action by providing mechanisms of a priori substrate discrimination.
The considerable disparities of ψ and ω in MDS are the basis of maneuver discrimination.
The legal complaint names Kleiner Perkins as the defendant, on the basis of gender discrimination and retaliation.
In some societies, the law of equal opportunity forbids statistical discrimination when the basis of the discrimination is race or sex.
In 1990, WMATA was sued by Christine Townsend in the Washington federal district court on the basis of sexual discrimination.
It therefore describes the explicit recognition of distinguishable cues which constitutes the basis of somatosensory discrimination, and the decision [21].
The basis of speech discrimination deficits lie in deficits of neurophysiologic encoding along the auditory pathway.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com