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Power provides predictions for a multimeric structure arrangement on the basis of structural information about its subunits and experimental measures acting as search restraints (as recently shown for the assembly of aerolysin, Degiacomi et al., 2013).
Tripeptide as an activator of SIRT1 were screened on the basis of structural information by molecular docking and synthesized by solid phase method.
The aim of this work was to design a peptide inhibitor on the basis of structural information of the active site of p38α.
On the basis of structural information and mutation analysis data, we identified candidate positions for accumulative histidine substitutions to cause electrostatic repulsion under acidic conditions.
Although SMD provides an approach to investigate the binding/unbinding events, yet the pulling direction of the force in SMD is chosen randomly or by guessing on the basis of structural information, which makes that the force applied to the ligand in such chosen directions may not move it along a favorable pathway.
Alternatively, the search is possible on the basis of structural information, allowing retrieval of all the pig sequences with the same structural characteristics.
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This post-processing has two benefits: to guide later segmentation, and to lay a basis for the calculation of structural information after segmentation is complete.
First of all, these experiments provide validation and improvements of computational predictions, thus increasing the accuracy of structural information forming the basis for rational design.
The structural basis for this effect cannot yet be defined because of the lack of structural information regarding complexes of MtATP-PRT and the two substrates or products, with and without l-histidine.
On the basis of available structural information, we propose that the activating substitutions destabilize the inactive conformation of MEK1, resulting in its constitutive activity and making it more prone to Raf-mediated phosphorylation.
It carries no expectation that its truth can be predicted on the basis of purely structural information.
More suggestions(15)
basis of structural color
basis of structural topology
basis of current information
basis of opaque information
basis of preliminary information
basis of direct information
basis of statistical information
basis of minimal information
basis of imperfect information
basis of genetic information
basis of inside information
basis of structural analysis
basis of inadequate information
basis of qualitative information
basis of new information
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