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Interestingly, a dendrogram generated solely on the basis of structural dissimilarity measure at the level of domain folds was found to cluster functionally similar members.
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Here, we investigate different ways of obtaining localized measures of structural dissimilarity and describe RNAsnp, a tool geared toward evaluating SNP effects on large data sets that is more sensitive to local structural change than the available methods.
The Minimal Structural Domain Set contains 1882 domains defined purely on the basis of structural compactness.
The other three promiscuous substrates, 11-phenoxyundecanoic acid (11PA), 2-phenoxyethanol (2PE), and 1,2-methylenedioxybenzene (MDOB), are organic compounds of increasing structural dissimilarity to 12-pNCA.
The dramatic difference in model performance between the test and the validated training sets can be explained by structural dissimilarity of the sets.
The number was surprisingly high, suggesting strong sequence and structural dissimilarity of Streptomyces sRNAs.
The sequence and structural dissimilarity of the predicted Streptomyces sRNAs demonstrated by this study serve as the first evidence of the uniqueness of Actinomyces sRNAs.
Figure 10 Structural dissimilarity map of the first two frames of the continuous-tone caltrain sequence.
For each network, we then used average linkage hierarchical clustering to group genes on the basis of TO dissimilarity measure (1 – TO).
The 3-D superimposition of protein structures obtained by using structure comparison tools is very useful in quantifying structural dissimilarity and in analyzing structural divergence.
In addition to the visual quality, the performance of the proposed filter was measured by the following criteria: PSNR, mean absolute error (MAE), and structural dissimilarity (DSSIM).
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