However, the mechanism of action and the structural basis of substrate specificity of rhomboids remain unresolved, largely due to the absence of structural analyses of rhomboid substrate complexes.
On the basis of the structural analyses, the five exocyclic lesions tested in this work should be able to adopt conformations that place the alkyl groups in the vicinity of the catalytic Fe(II) center of AlkB, allowing the enzyme to oxidize and dealkylate the modified bases.
On the basis of the TLC and structural analyses of lipids which accumulate in the presence of TAC or SRI-224, designated here as X and Y, cyclopropanation appeared to be the site of action of the drugs, in particular, cyclopropanation of the proximal double bond.
The Minimal Structural Domain Set contains 1882 domains defined purely on the basis of structural compactness.
Endres and co-workers proposed a similar model on the basis of detailed biochemical and structural analyses of the EGFR.
On the basis of the above observations and structural analyses, we conclude that both of the BTs and PCTs can provide larger and rougher surface areas than the TNTAs compared with the arrays of same geometrical size and quantity [7, 34, 35].
Moreover, on the basis of DNA analyses and structural considerations, their possible evolution is traced.
Complementing the molecular studies of ER regulation, structural analyses of the ER LBD have shed further light on our understanding of ER function, in particular its interaction with coactivators and the structural basis of receptor agonism and antagonism.
To understand the molecular basis of the Swi1-Swi3 replication fork protection complex, we performed structural analyses of the Swi3 protein at the amino acid sequence level.
Also, structural analyses of members of the PPP family have begun to reveal the molecular basis for catalysis, inhibition by toxins, and aspects of their regulatory mechanisms.
