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Allelic polymorphism of target antigens in natural populations of T. parva is a key issue for understanding the basis of strain specificity in immunity to the parasite.
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The basis for the strain specificity was likely a complex set of background modifiers.
Chen, Y. et al. Crystallography of a lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens.
In addition, the genetic basis of host-specificity of strains of the fire blight pathogen for plants of two subfamilies of the Rosaceae family of plants was explored.
In order to describe the genetic basis of this specificity of Xff strains compared to most other xanthomonads, we analyzed the tyrosine degradation pathway (http://biocyc.org/META/new-image?object=TYRFUMCAT-PWY).
The strain specificity of vaccines presently in use mirrors the exquisite specificity of the neutralizing antibodies that they induce, that is, antibodies which bind to the highly variable globular head domain of hemagglutinin (HA).
Kinetics and strain specificity of rhizosphere and endophytic colonization by enteric bacteria on seedlings of Medicago sativa and Medicago truncatula.
Strain specificity of Campylobacter phages.
The hyperimmune rabbit antisera were chosen on the basis of their ability to provide a broad response, which would recognize a wide range of strains within 1 subtype, whereas the postinfection ferret antisera were chosen on the basis of high specificity.
Previous studies have implicated the homeodomain as a major determinant of biological specificity within these proteins, but have not established the physical basis of this specificity.
We are gaining an understanding of the molecular basis of resistance specificity and of the natural processes that generate different specificities.
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