The atomic model of the complex was refined using data to 2.3 Å resolution and revealed a unique H-bonding pattern that constitutes the molecular basis of specificity for the HMP moiety of thiamin.
The clear one-to-one orthology between human and Ciona G protein repertoires that extends at the levels of protein family, subfamily and type, indicates a strong conservation in the evolution of the mechanistic basis of specificity and diversity of the chordate GPCR signaling pathways.
In a previous prospective multicenter cohort study, it was reported that, on the basis of specificity, positive predictive value, and AUC, rSO2 of >42% at hospital arrival was an excellent neurologic prognostic index in OHCA (including patients who received ongoing CPR) and that rSO2 also had advantages over base excess [ 25].
Amino acids assembled by 14 of these 29 A-domains were predicted on the basis of specificity-conferring signatures of A-domains (Additional file 1; see Figure 3).
Amino acids assembled from 21 of these 33 A-domains were predicted on the basis of specificity-conferring signatures of A-domains.
Ten out of 17 amino acids assembled by the locus META-B of strain BAI3 were predicted on the basis of analysis of specificity-conferring signatures of A-domains (Additional file 1; see Figure 3).
On the basis of substrate specificity, they are classified as serine/threonine, tyrosine, dual specificity, or histidine protein phosphatases.
The test is specific to GSH on the basis of the specificity of the GSH reductase enzyme to GSH: the rate of accumulation of TNB is proportional to the concentration of GSH in the sample.
We are gaining an understanding of the molecular basis of resistance specificity and of the natural processes that generate different specificities.
The current study sheds light on the structural basis of substrate specificity of type-II FPPS of the spruce budworm.
To characterize the structural basis of sequence specificity and flexibility of the Escherichia coli Hsp70 chaperone DnaK, we have analyzed crystal structures of the substrate binding domain of the protein in complex with artificially designed peptides as well as small proline-rich antimicrobial peptides.
