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We highlight new positions for these proteins that suggest additional experiments to elucidate the basis of specificity.
The atomic model of the complex was refined using data to 2.3 Å resolution and revealed a unique H-bonding pattern that constitutes the molecular basis of specificity for the HMP moiety of thiamin.
However, the molecular basis of specificity between the Rep protein and the viral origin of replication between different AAV serotypes remains uncharacterized.
Whilst such mechanistic studies suggest a possible basis of specificity, little work has yet been carried out to directly test whether there is specificity in the interaction between host immune responses and parasite types.
The clear one-to-one orthology between human and Ciona G protein repertoires that extends at the levels of protein family, subfamily and type, indicates a strong conservation in the evolution of the mechanistic basis of specificity and diversity of the chordate GPCR signaling pathways.
This approach would essentially unravel the molecular basis of specificity at individual level that ultimately dictates the cellular physiology leading to the phenome variation.
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Amino acids assembled by 14 of these 29 A-domains were predicted on the basis of specificity-conferring signatures of A-domains (Additional file 1; see Figure 3).
Amino acids assembled from 21 of these 33 A-domains were predicted on the basis of specificity-conferring signatures of A-domains.
Nitrilases have been classified into three major categories on the basis of substrate specificity, although some nitrilases exhibit broad substrate specificity.
On the basis of substrate specificity, they are classified as serine/threonine, tyrosine, dual specificity, or histidine protein phosphatases.
The test is specific to GSH on the basis of the specificity of the GSH reductase enzyme to GSH: the rate of accumulation of TNB is proportional to the concentration of GSH in the sample.
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CEO of Professional Science Editing for Scientists @ prosciediting.com