Sentence examples for basis of single gene from inspiring English sources
Although significant progress has been made towards unraveling the basis of single gene stroke disorders and common ischaemic stroke [5], [6], identifying the underlying genes for multifactorial haemorrhagic stroke for which there is no obvious Mendelian pattern of inheritance, has proved difficult.
The majority of NTDs are sporadic, with recurrence fitting a multifactorial polygenic or oligogenic pattern, rather than models on the basis of single gene dominant or recessives, with reduced penetrance (2).
Clinical translation of genetic markers can take place even in the absence of a complete understanding of their functional biologic significance The use of linkage or "reverse genetics" led to discoveries of the basis of single gene disorders, such as hemophilia, cystic fibrosis, and breast cancer (reviewed in Botstein and Risch 2003).
Geneticists have made much progress pinning down the genetic basis of single-gene disorders, but the roots of more complex diseases have been elusive.
Nonetheless, all three probesets could form the basis of single-gene classifiers with wide classifier margins.
Comparative studies of the molecular basis of single-gene mutants selected under domestication may therefore be more informative with regard to multiple origins of traits of the domestication syndrome.
A comprehensive list of single gene disorders and their molecular basis can be found online (www.ncbi.nlm.nih.gov/omim/).nih.gov/omim/
In the example shown in Figure 1C, the primer pair mv_B0432.8 was designed on the basis of a single gene model that existed until 2003.
However, most studies on the genetic basis of alcohol sensitivity have focused on effects of single genes.
In all these species, the change of single genes has brought noticeable increases in life span.
Differentiation between HDACi and mercurials is relatively easy in the present set of data and could even be achieved on the basis of only single genes, such as FOXD3 (Fig. 7).
