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MicroRNA silences gene expression by targeting specific mRNAs on the basis of sequence recognition [ 12].
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In order to examine the physical basis of indirect sequence recognition and to expand the number of such nucleases available for genome engineering, we have determined the target sites, DNA-bound structures, and central four cleavage fidelities of nine related enzymes.
Successful implementation of this strategy will be more challenging, as it will demand a thorough understanding (currently lacking) of the structural basis for DNA sequence recognition by the catalytic domain.
GSK3 does not recognize its targets on the basis of simple primary sequence recognition but a priming phosphorylation event is required [ 30].
The concept of patterns is the basis of sequence analysis.
Exact molecular basis underlying H3 distal sequence recognition calls for complex structure determination in the future.
The DBD and the LBD of the PPARs determine the specificity of promoter DNA sequence recognition and ligand recognition, respectively.
The goal was to characterise the sequence and structure of CALA in comparison to other α/β hydrolases despite its low sequence similarity and to understand the molecular basis of substrate recognition.
Yet little is known about the neural basis of voice recognition in any species.
Structural studies have revealed the molecular basis of DNA recognition by TALE repeats.
As the basis of image recognition, such information can provide sample training and quick identification.
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