Sentence examples for basis of selectivity of from inspiring English sources

Structure-based approach was used to investigate the basis of selectivity of the compounds with experimentally observed activity.

3D models of human PR and AR with this ligand were constructed to investigate the molecular basis of selectivity.

Ultimately, the success of any approach demands a full understanding of the fundamental basis of selectivity.

Rigorous testing of noninvasive technologies must be continued in concert with efforts to understand the underlying chemical basis of selectivity.

Inhibitors were selected on the basis of evidence of selectivity, suppression of endometrial cell inflammatory responses to LPS, and preliminary experiments showing reduced phosphorylation of MAPK (Supplemental Figure 1 published on The Endocrine Society's Journals Online web site at http://end.endojournals.org) (18, 25, 26).

They can be useful for the discovery of new pharmaceutical leads, the validation of new biotargets and the determination of the structural basis of ligand selectivity within target families.

This series was evaluated on the basis of potency, selectivity, and rat pharmacokinetic parameters.

On the other hand, the channel can be further categorized on the basis of time selectivity conditions.

In humans, the structural basis of the selectivity of genistein for ERβ versus ERα has been linked to two critical positions in the ligand binding pocket, Met 336 and Ile 373, which are replaced by a Leu and a Met respectively in ERα ([23]; see Figure 6A).

The molecular basis of this selectivity remains unknown.

To examine the structural basis of this selectivity, we compared the sequences and structures of these two proteins.