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It will be interesting to know the basis of relaxed specificity in going from AMSH to AMSH3 and if the dynamic nature of the flap is an underlying factor.
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The answers to these questions are important in providing an evolutionary and functional context for the evolution of these new LDH genes and the possible functionality of ancestral enzymes of relaxed specificity.
Pathway analysis, using genes selected on the basis of relaxed criteria, revealed notable differences between these two traits.
These genetic experiments define two positions in GlnRS where amino acid substitution results in a relaxed specificity of tRNA discrimination.
It is likely that AnaABCDE produce all four anabaenopeptin variants due to relaxed specificity of the AnaA1 and AnaA2 domain.
Previous studies have implicated the homeodomain as a major determinant of biological specificity within these proteins, but have not established the physical basis of this specificity.
β-Glucosidases may be classified into three groups on the basis of substrate specificity.
The genetic basis of host specificity for animal and plant pathogenic bacteria remains poorly understood.
On the basis of substrate specificity, they are classified as serine/threonine, tyrosine, dual specificity, or histidine protein phosphatases.
Understanding the genetic and molecular basis of host specificity in pathogenic bacteria is of great importance.
What is the mechanistic basis of the specificity of dPob towards multispan membrane proteins?
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