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An apriori, hypothesis-driven functional region of interest (fROI) was chosen on the basis of prior data [21] demonstrating significant cross-sectional differences in activation from healthy elderly controls to AD subjects.
This new weighted FDR methodology involves weighting the association test p-values on the basis of prior data derived from linkage.
On the basis of prior data indicating that sex hormones tend to be more strongly associated with estrogen receptor (ER -positive disER -positive 6], we evaluatediseasecores for this subset of tumors.
On the basis of prior data, the overall prevalence of esophageal squamous cell carcinoma in patients with achalasia has been estimated to be up to 8.6%, accounting for a 50-fold increase in cancer risk [ 7].
On the basis of prior data (de Gramont et al, 1997a), patients who receive continuous 5-FU might have less adverse effects than those treated with bolus 5-FU.
On the basis of prior data from surveillance of source populations, our results were not likely explained by the null hypothesis of infections introduced from the source populations (p = 0.036 for academy source deer and p < 0.0001 for refuge source deer).
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IPA ranked networks depending on the reliability of the microarray results on the basis of prior published data.
This study shows that the MonoNose can identify pathogenic bacteria during the first few hours of growth on the basis of prior calibration data generated by other MonoNoses.
Cytokines and pharmacological inhibitor doses were selected on the basis of prior dose response experiments (data not shown) or previously published literature [ 15].
On the basis of prior research and the data available to this study, we posited that a "risk predisposition" for both migration and HIV infection will be associated with age, employment status, education level, marital/partnership status, and measures of household socio-economic status (using infrastructure variables and tertiles of the number of assets).
Selection of a systems model structure is usually based on different considerations on the basis of prior knowledge of the underlying mechanism only, available data and/or prior knowledge of the mechanism, or a desire to explore the ability of unknown mechanisms to describe data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com