In commissioning the trial, the Department of Health Policy Research Programme that funded the trial specified inclusion of prenatal tobacco use, childhood injuries requiring emergency department attendance or admission, and inter-birth interval as primary outcome measures that were considered on the basis of previous trials to be modifiable by FNP.
The intravenous magnesium sulphate dosage used in the MagPEP-study was chosen on the basis of previous trials investigating the effect of magnesium sulphate on multiple other conditions, including asthma, traumatic brain injury, acute myocardial infarction, premature labour, and stroke.
On the basis of previous trials with biologics in AS, it was assumed that the response rates would be 25% in the placebo group and 60% in at least one of the active treatment groups.
On the basis of previous trials with liraglutide, the trough value is estimated to be 20 000 pmol/l during steady state and the SD is estimated to be 8000 pmol/l in participants with normal kidney function.
20 30 Although we expected, on the basis of previous trials, that improvement due to the intervention would be sustained, we did not anticipate that the longer term benefit would be greater than the short term benefit.
Estimating effect-size on the basis of previous trials summarized in meta-analyses using the HDRS-17 in psychosocial treatments, with or without pharmacological therapies (e.g. [ 45]), we could achieve the target levels of alpha and beta with 80 cases randomised equally into two arms.
Also, the authors selected DAS44 (44-joint disease activity score) as the main evaluation technique, and the sample size was also calculated on the basis of results of previous trials in rheumatoid arthritis (RA).
On the basis of a previous trial of physical therapy in Parkinson's disease, 37 we expected a dropout rate of 10%.
On the basis of the result of previous trials, the 3-year RFS rate in the Mf group was estimated to be 60%.
Until recently, on the basis of previous clinical trial results [ 27], 5 years of tamoxifen was the standard adjuvant treatment for PMW with HR+ EBC.
