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Each of these 13 MEME runs identified the top 20 motifs that were more common than expected on the basis of nucleotide composition.
This process is known as amelioration, and implies that the original sequence can no longer be recognised as that from a foreign origin on the basis of nucleotide composition alone [ 24].
The perfect match only design employed for this array compares favorably with a small-scale analysis including mismatch controls (for chromosome Ib only), and preliminary results indicate that small differences in sensitivity at low expression levels can be restored using a pool of surrogate mismatch probes selected on the basis of nucleotide composition (Additional File 1).
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We used the program MEGA version 4.0 [ 64] to obtain estimates of nucleotide composition, nucleotide pair frequencies, and codon usage.
However, 7 of 17 families are novel according to the classification of nucleotide composition of TSD.
The common ancestor of this plant family underwent a transition of nucleotide composition.
Moreover, the polarisation of nucleotide composition is suggested to affect the replication-directed architecture of genomes.
This suggests the possible use of nucleotide composition analysis to predict expression patterns of viral genes.
We found that each TF exhibits a range of nucleotide composition environments in which it binds.
Reviewer #3 This study examines the role of nucleotide composition in RNA virus genomes.
We then tested the effect of nucleotide compositions at 5′/3′ ends on read counts.
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