Igu, which is a C2H2 zinc finger-coiled-coil domain protein, was originally proposed, on the basis of the mutant phenotypes and localization of an overexpressed Igu-GFP fusion protein, to regulate the nuclear-cytoplasmic shuttling of Gli proteins.
Accordingly, the molecular basis of the mutant phenotype may be due to the lack of a protein(s) that is/are important for normal visual transduction.
Melanic (darkly pigmented) phenotypes in mammals provide a potent system in which to study the genetic basis of naturally occurring mutant phenotypes because melanism occurs in many mammals, and the mammalian pigmentation pathway is well understood.
Modifier of pma1 (mop) mutants were isolated as enhancers of the mutant phenotypes of pma1 mutants.
GO annotations may be assigned on the basis of several different types of evidence, including mutant phenotypes, so there can be some overlap between GO annotations and phenotype annotations.
None of these mutant phenotypes was recapitulated in Dsp mutants.
On the basis of the segregation of eyespot and embryonic mutant phenotypes in the experimental crosses, we propose that the three mutations occurred in the BE/ Fr/ Spr (BFS) locus, and that two of them are embryonic recessive lethal.
On the basis of the phenotypes of the mutant and overexpressors (complemented lines), it is highly likely that MpSIG1 is involved in the transcription of a wide range of transcripts and that its function overlaps with and/or is complemented by those of other sigma factors.
A role for sterols as essential components of vascular patterning is evident from biosynthesis mutant phenotypes, but the molecular basis of their actions is not well understood.
An alignment showing sequence conservation between FolA and some of its homologs, demonstrating a possible structural basis for the folA1 mutant phenotype, is shown in Figure S2.
