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Understanding the molecular basis of kidney development will help us to develop regenerative therapies for kidney diseases.
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The added resolution of RNA-Seq has provided the basis for a transition from classical gene-centric models of kidney development towards more accurate and detailed "transcript-centric" representations, which highlights the extent of transcriptional complexity of genes that direct complex development events.
We have previously described a gene expression atlas of kidney development, at microanatomic resolution [17].
The obvious solution to this would appear to be gene expression analysis of kidney development.
Although genes involved in kidney organogenesis or associated with kidney disease have been identified, there is still limited molecular genetic knowledge of kidney development and homeostasis.
We hypothesized that maternal PEM diminishes availability of fetal macro- and micronutrients to compromise development of the fetal kidney vasculature, effects that underpin nutritional programming of kidney development.
Wnt signaling is of critical importance in several stages of kidney development.
There was no exclusion on the basis of kidney disease.
This confirmed the impossibility to distinguish among these conditions solely on the basis of kidney function assessment or proteinuria.
Studies have shown that WT cells express markers of early kidney development [28, 29].
Lhx1 also plays an important role at multiple stages of mammalian kidney development.
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