Sentence examples for basis of its binding from inspiring English sources

The authors have cloned an IL-10-responsive DNA-binding protein on the basis of its binding to the HTE-1 sequence, and explored its function.

Although the nonspecific nature of zVAD binding has allowed us to characterize the aforementioned pathway, we cannot ascertain the identity of its target protease on the basis of its binding to zVAD alone.

Namely, a proinflammatory role of MBL also has been described on the basis of its binding to agalactosyl IgG, which can activate the complement system [ 3] and therefore lead to increased inflammation [ 1].

The activity of Nox4 can be modestly stimulated by a DNA polymerase-interacting protein POLDIP2, which was first suggested to regulate Nox1 and Nox4 on the basis of its binding in a yeast two-hybrid screen to p22 phox ; however, the biological significance of this interaction is unclear, and Nox4 is not generally considered to be acutely regulated by subunit interactions.

This complex is thought to assemble on the 3′ end of deadenylated mRNAs on the basis of its binding specificity in vitro (Chowdhury et al. 2007) and the exonuclease trimming of the 3′ end of deadenylated mRNAs in pat1 Δ or lsm1 Δ strains (Boeck et al. 1998; Tharun et al. 2000; He and Parker 2001).

The humanized HER2-specific scFv chA21 was selected on the basis of its high binding affinity for HER2 (KD = 11 nm) [ 17].

Serotype 6C was identified in 2007 on the basis of its distinct binding patterns with 2 monoclonal antibodies; serotype 6C had previously been typed as 6A according to the standard quellung reaction.

Trabucchi et al. [6] suggested that KSRP is a key regulator of the processing of a sizeable subset of miRNA precursors (miR-1, miR-15, miR-16, miR-20a, miR-21, miR-26b, miR-27b, miR-106a, miR-125, miR-196, miR-206 and let-7) on the basis of its high-affinity binding to their terminal loop.

HscA is thus vital to the maturation of Fe S proteins, yet the structural basis of its unique nucleotide binding and dissociation features has remained unresolved, for no atomic-level information about HscA's NBD has been reported.

Favorable interactions of the additional Val-5 residue highlight direct and indirect structural basis of its contribution to increased binding affinity.

On the basis of its possible Ca(2+ -binding property, LETM1 was found to be involved in Ca(2+ -bindingng and/or homeostasis.