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"To formulate a policy on the basis of instability is a recipe for failure," Mr. Pascual said.
The deformation and fracture mechanisms of polypropylene (PP) have been analysed on the basis of instability of plastic deformation in the region of preformed voids under dilatational stress.
While the molecular basis of instability is well understood in hereditary cancers, where it is linked to mutations in DNA repair genes, the basis of instability in sporadic cancers remains poorly defined.
Based on such karyotypic complexity, several attempts have been done to provide clues on the molecular basis of instability by using different approaches (gene expression analysis, DNA-based techniques, and deep genome sequencing).
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An in-depth understanding of the mechanisms by which these complexes promote DNA repair and genomic stability may help us to uncover the molecular basis of genomic instability in human cancers and devise ways that exploit this instability to treat cancers.
Lawyers I talk to say Gu may end up with a fate that is common in knotty Chinese cases: a death sentence that is suspended (i.e., never carried out), on the basis of mental instability.
In this study, a theoretical basis of thermomechanical instability during the solidification of pure metals on a coated planar mold is presented.
In this regard, recent studies have shed new light on the molecular basis of genome instability and DNA damage responses in these cells.
Disruption of CCND1, that encodes for cyclin D1, involved in the regulation of the G1/S transition of the cell cycle (Bringuier et al, 1996), may form the basis of genetic instability (Reznikoff et al, 2000).
The possibility to classify breast tumours accurately into risk groups on the basis of genomic instability together with information about proliferation is an implication of practical clinical relevance of this study.
Integration of knowledge generated through steps 5 and 6 in order to explain somatic cancer evolution in individual patients on the basis of genetic instability, external selection forces and the internal effects of the genome architecture on genes and regulatory elements.
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