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The power of adaptive evolutionary strategies is expected to increase with the rapid development of whole-genome sequencing, which, combined with gene expression and metabolic flux analysis, enables the identification of the genetic basis of improved phenotypes and the transfer of such phenotypes between strains.
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Given the vastly improved fermentative performance of strain #7 over 8b in regards to xylose utilization and the tolerance of inhibitors, we wanted to identify the underlying genetic basis for this improved phenotype.
Improved phenotyping of the syndrome may help improve therapeutic strategies.
To improve phenotyping of AKI, many urinary biomarkers of tubular injury are being investigated.
Williams, J. H. et al. Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of spinal muscular atrophy.
The CPRD is much larger than the UK biobank and would be particularly valuable to improve our understanding of the genetic basis of rarer phenotypes, if these could be linked to biological samples.
Understanding the genetic basis of domesticated phenotypes has dual relevance to evolutionary biology and crop improvement.
Chong, J. X. et al. The genetic basis of mendelian phenotypes: discoveries, challenges, and opportunities.
Progress in the field of strain engineering is being made by identifying the genetic basis of complex phenotypes, engineering new phenotypes, and combining beneficial phenotypes in industrial hosts.
Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested.
The lack of knowledge on the genetic basis of complex phenotypes restricts our ability to rationally engineer them.
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