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In summary, the methods proposed in our study could potentially play an important role in miRNA research and serve as a powerful tool for further elucidation of the molecular basis of human pathologies.
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Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility.
Our current findings unveil a mechanistic connection between p27 and SOX2, and thereby contribute to our understanding of the molecular basis of the human pathologies associated with the deregulation of these two proteins.
Table 1 A comparison of the relative strengths and weaknesses of human pathology and computational histologic image analysis.
Accurate modeling of human pathology remains challenging but is essential to draw relevant conclusions from experiments.
We use genetic approaches to identify the molecular basis of human disease pathology.
This work was supported by the following grants to R.S.A.: Fondazione Cariplo 2008-2230 'Cellulandand molecular basis of human retroviral-dependent pathology'; A.I.R.C IG 8862 ' New strategies of tumor vaccination and immunotherapy based on optimized triggering of anti-tumor CD4+ T cells'; MIUR-PRIN project 2008-WXF7KK 'New strategies of immunointervention against tumors'.
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These things form the basis of human rights.
Defective protein folding as a basis of human disease.
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